HOME/東京都健康長寿医療センター研究所 老化制御研究チーム 分子老化制御

研究実績 2017 2016 2015 2014 2013 2012 2011
2010 2009 2008年以前

研究実績 2013年

原著論文 総説および解説

原著論文

  1. Miyata, M., Suzuki, S., Misaka, T., Shishido, T., Saitoh, S.I., Ishigami, A., Kubota, I., Takeishi, Y. : Senescence Marker Protein 30 Has a Cardio-Protective Role in Doxorubicin-Induced Cardiac Dysfunction. PLoS One 8, e79093 (2013)
  2. Jeong, D.H, Hwang, M., Park, J.K., Goo, M.J., Hong, I.H., Ki, M.R., Ishigami, A., Kim, A.Y., Lee, E.M., Lee, E.J., Jeong, K.S. : Smad3 deficiency ameliorates hepatic fibrogenesis through the expression of senescence marker protein-30, an antioxidant-related protein. Int. J. Mol. Sci. 14, 23700-23710 (2013)
  3. Maruoka, H., Kishimoto, Y., Ishigami, A. : The effect of vitamin C C-onsumption on the oxidative stress regulation system in SMP30/GNL knockout mice. Jpn. J. Compl. Alternative Med. 10, 63-68 (2013)
  4. Kagami, Y., Kondo, Y., Handa, S., Maruyama, N., Ishigami, A. : Senescence Marker Protein-30/Gluconolactonase Expression in the Mouse Ovary during Gestation. Biol. Pharm. Bull. 36, 2005-2008 (2013)
  5. Amano, A., Sato, Y., Kishimoto, Y., Takahashi, K., Handa, S., Aigaki, T., Maruyama, N., Ishigami, A. : Effects of ascorbic acid deficiency on protein and lipid oxidation in livers from SMP30/GNL knockout mice. J. Nutr. Sci. Vitaminol. 59, 489-495 (2013)
  6. Misaka, T., Suzuki, S., Miyata, M., Kobayashi, A., Ishigami, A., Shishido, T., Saitoh, S., Kubota, I., Takeishi, Y. : Senescence marker protein 30 inhibits angiotensin II-induced cardiac hypertrophy and diastolic dysfunction. Biochem. Biophys. Res. Commun. 439, 142-147 (2013)
  7. Misaka, T., Suzuki, S., Miyata, M., Kobayashi, A., Shishido, T., Ishigami, A., Saitoh, S.I., Hirose, M., Kubota, I., Takeishi, Y. : Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodelling. Cardiovasc. Res. 99, 461-470 (2013)
  8. Kondo, Y., Hasegawa, G., Okada, H., Senmaru, T., Fukui, M., Nakamura, N., Sawada, M., Kitawaki, J., Okanoue, T., Kishimoto, Y., Amano, A., Maruyama, N., Obayashi, H., Ishigami, A. : Leprdb/db Mice with Senescence Marker Protein-30 Knockout (Leprdb/dbSmp30Y/-) Exhibit Increases in Small Dense-LDL and Severe Fatty Liver Despite Being Fed a Standard Diet. PLoS One 8, e656982013 (2013)
  9. Mizukami,H., Saitoh, S., Machii, H., Yamada, S., Hoshino, Y., Misaka, T., Ishigamai, A., Takeishi, Y. : Senescence marker protein-30 (SMP30) deficiency impairs myocardium-induced dilation in coronary arterioles associated with reactive oxygen species. Int. J. Mol. Sci. 14, 9408-9423 (2013)
  10. Tanisawa, K., Mikami, E., Fuku, N., Honda, Y., Honda, S., Ohsawa, I., Ito, M., Endo, S., Ihara, K., Ohno, K., Kishimoto, Y., Ishigami, A., Maruyama, N., Sawabe, M., Iseki, H., Okazaki, Y., Hasegawa-Ishii, S., Takei, S., Shimada, A., Hosokawa, M., Mori, M., Higuchi, K., Takeda, T., Higuchi, M., Tanaka, M. : Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes. BMC Genomics 14, 248 (2013)
  11. Yamada, S., Saitoh, S.I., Machii, H., Mizukami, H., Hoshino, Y., Misaka, T., Ishigami, A., Takeishi, Y. : Coronary Artery Spasm Related to Thiol Oxidation and Senescence Marker Protein-30 in Aging. Antioxid. Redox Signal. 19, 1063-1073 (2013)
  12. Kishimoto, Y., Kanai, T., Sato, K., Lee, J., Jeong, K.S., Shimokado, K., Maruyama, N., Ishigami, A. : Insufficient ascorbic acid intake during gestation induces abnormal cardiac dilation in fetal and neonatal SMP30/GNL knockout mice. Pediatr. Res. 73, 578-84 (2013)
  13. Hoshino, Y., Yamada, S., Saitoh, S.I., Machii, H., Mizukami, H., Miyata, M., Misaka, T., Ishigami, A., Takeishi, Y. : Age-related oxidant stress with senescence marker protein-30 deficiency plays a pivotal role in coronary artery spasm. Coron Artery Dis. 24, 110-118 (2013)
  14. Aizawa, S., Senda, M., Harada, A., Maruyama, N., Ishida, T., Aigaki, T., Ishigami, A., Senda, T. : Structural Basis of the γ-Lactone-Ring Formation in Ascorbic Acid Biosynthesis by the Senescence Marker Protein-30/Gluconolactonase. PLoS One 8, e53706 (2013)
  15. Kishimoto, Y., Saito, N., Kurita, K., Shimokado, K., Maruyama, N. Ishigami, A. : Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts. Biochem. Biophys. Res. Commun. 430, 579-84
  16. Kim, H.S., Son, T.G., Park, H.R., Lee, Y., Jung, Y., Ishigami, A., Lee, J. : Senescence marker protein 30 deficiency increases Parkinson's pathology by impairing astrocyte activation. Neurobiol. Aging 34, 1177-1183 (2013)
  17. Jang, B., Ishigami, A., Maruyama, N., Carp, R.I., Kim, Y.S., Choi, E.K. : [Mini-Review] Peptidylarginine deiminase and protein citrullination in prion diseases: Strong evidence of neurodegeneration. Prion 7, 42-46 (2013)
  18. Amano, A., Tsunoda, M., Aigaki, T., Maruyama, N., Ishigami, A. : Age-related changes of dopamine, noradrenaline, and adrenaline in adrenal glands of mice. Geriatr. Gerontol. Int. 13, 490–496 (2013)
  19. Ishigami, A., Uchida, Y., Miyazaki, T., Handa, S., Choi, E.K,, Kim, Y.S,, Kasahara, Y., Maruyama, N. : Two novel sandwich ELISAs identify PAD4 levels and PAD4 autoantibodies in patients with rheumatoid arthritis. Mod Rheumatol. 23, 794-803 (2013)
  20. Kim, A.Y., Lee, E.M., Lee, E.J., Min, C.W., Kang, K.K., Park, J.K., Hong, I.H., Ishigami, A., Tremblay, J.P., Jeong, K.S. : Effects of vitamin C on cytotherapy-mediated muscle regeneration. Cell Transplant. 22, 1845-1858 (2013)

総説および解説

  1. 石神昭人 : ビタミンCの不足が胎児の発生や成長、老化や老年病に及ぼす影響(ミニレビュー). Trace Nutrients Research 30: 97-100 (2013)
  2. 湯浅正洋、橋本知美、松本希美、澤村弘美、松井朝義、岸本祐樹、石神昭人、渡邊敏明 : 災害後の避難所における食事およびビタミン強化食品による体内ビタミン栄養状態への影響. Trace Nutrients Research 30: 7-12 (2013)
  3. 石神昭人 : 胎児の発生や小児の成長、高齢期におけるビタミンCの必要性. ビタミン 87: 665-668 (2013)
  4. 増冨裕文、石神昭人 : ビタミンCによる結核治療の可能性. ビタミン 87: 632-634 (2013)
  5. 山本憲朗、石神昭人 : ビタミンC は尿路結石のリスク因子か?. ビタミン 87: 575-578 (2013)
  6. 岸本祐樹、金井孝夫、佐藤加代、Jaewon Lee、Kyu-Shik Jeong、下門顕太郎、丸山直記、石神昭人 : 妊娠期間中のビタミンC摂取不足が胎児や新生児に異常な心拡張を引き起こす. ビタミン 87: 549-550 (2013)
  7. 天野晶子、石神昭人: ビタミンCとナトリウム依存性ビタミンCトランスポーター(SVCT)の遺伝子多型. ビタミン 87: 492-496 (2013)
  8. 高橋経太、石神昭人: 幹細胞とアスコルビン酸. ビタミン 87: 446-449 (2013)
  9. 濱野慶朋、丸山直記、湯村和子、鈴木和男 :高齢者に多い腎疾患の診断と治療:血管炎症行群. Geriatric Medicine 51:593-602 (2013)
  10. 丸山直記、濱野慶朋 :老化研究の進歩:腎病変を修飾する加齢要因. Geriatric Medicine 51:615-618 (2013)
  11. 佐藤安訓、新井浩司、西山敏夫、野村義宏、岸本祐樹、相澤真悟、丸山直、石神昭人 : ビタミンC欠乏は表皮萎縮およびUVB 照射による色素沈着を増加する:SMP30/GNL-ノックアウトヘアレスマウスでの解析. ビタミン 87 13-14 (2013)
  12. 石神昭人 : ビタミンCの摂取における野菜の有効性について. 野菜情報 106 36-41 (2013)

 

 

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